Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival

BACKGROUND: Through several not-fully-characterised moonlighting functions, translation elongation factor eEF1A2 is known to provide a fitness boost to cancer cells. Furthermore, eEF1A2 has been demonstrated to confer neoplastic characteristics on preneoplastic, nontumourigenic precursor cells. We h...

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Detalles Bibliográficos
Autores principales: Losada, Alejandro, Muñoz-Alonso, María José, Martínez-Díez, Marta, Gago, Federico, Domínguez, Juan Manuel, Martínez-Leal, Juan Fernando, Galmarini, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265344/
https://www.ncbi.nlm.nih.gov/pubmed/30420615
http://dx.doi.org/10.1038/s41416-018-0336-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265344/
https://www.ncbi.nlm.nih.gov/pubmed/30420615
http://dx.doi.org/10.1038/s41416-018-0336-y

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