Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1(-/-) mouse brains. Pin1 binds to phosphorylated CaMKII and...

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Detalles Bibliográficos
Autores principales: Shimizu, Taiki, Kanai, Kenta, Sugawara, Yui, Uchida, Chiyoko, Uchida, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265371/
https://www.ncbi.nlm.nih.gov/pubmed/30532705
http://dx.doi.org/10.3389/fphar.2018.01351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265371/
https://www.ncbi.nlm.nih.gov/pubmed/30532705
http://dx.doi.org/10.3389/fphar.2018.01351

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