Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1(-/-) mouse brains. Pin1 binds to phosphorylated CaMKII and...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimizu, Taiki, Kanai, Kenta, Sugawara, Yui, Uchida, Chiyoko, Uchida, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265371/
https://www.ncbi.nlm.nih.gov/pubmed/30532705
http://dx.doi.org/10.3389/fphar.2018.01351
_version_ 1783375628771262464
author Shimizu, Taiki
Kanai, Kenta
Sugawara, Yui
Uchida, Chiyoko
Uchida, Takafumi
author_facet Shimizu, Taiki
Kanai, Kenta
Sugawara, Yui
Uchida, Chiyoko
Uchida, Takafumi
author_sort Shimizu, Taiki
collection PubMed
description Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1(-/-) mouse brains. Pin1 binds to phosphorylated CaMKII and weakens its activity. For this reason, the phosphorylation level of tau in the presence of Pin1 is lower than that in the absence of Pin1, and microtubule polymerization is not downregulated by CaMKII when Pin1 is present. These results suggest a novel mechanism of action of Pin1 to prevent neurodegeneration.
format Online
Article
Text
id pubmed-6265371
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-62653712018-12-07 Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains Shimizu, Taiki Kanai, Kenta Sugawara, Yui Uchida, Chiyoko Uchida, Takafumi Front Pharmacol Pharmacology Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1(-/-) mouse brains. Pin1 binds to phosphorylated CaMKII and weakens its activity. For this reason, the phosphorylation level of tau in the presence of Pin1 is lower than that in the absence of Pin1, and microtubule polymerization is not downregulated by CaMKII when Pin1 is present. These results suggest a novel mechanism of action of Pin1 to prevent neurodegeneration. Frontiers Media S.A. 2018-11-23 /pmc/articles/PMC6265371/ /pubmed/30532705 http://dx.doi.org/10.3389/fphar.2018.01351 Text en Copyright © 2018 Shimizu, Kanai, Sugawara, Uchida and Uchida. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shimizu, Taiki
Kanai, Kenta
Sugawara, Yui
Uchida, Chiyoko
Uchida, Takafumi
Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains
title Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains
title_full Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains
title_fullStr Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains
title_full_unstemmed Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains
title_short Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains
title_sort prolyl isomerase pin1 directly regulates calcium/calmodulin-dependent protein kinase ii activity in mouse brains
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265371/
https://www.ncbi.nlm.nih.gov/pubmed/30532705
http://dx.doi.org/10.3389/fphar.2018.01351
work_keys_str_mv AT shimizutaiki prolylisomerasepin1directlyregulatescalciumcalmodulindependentproteinkinaseiiactivityinmousebrains
AT kanaikenta prolylisomerasepin1directlyregulatescalciumcalmodulindependentproteinkinaseiiactivityinmousebrains
AT sugawarayui prolylisomerasepin1directlyregulatescalciumcalmodulindependentproteinkinaseiiactivityinmousebrains
AT uchidachiyoko prolylisomerasepin1directlyregulatescalciumcalmodulindependentproteinkinaseiiactivityinmousebrains
AT uchidatakafumi prolylisomerasepin1directlyregulatescalciumcalmodulindependentproteinkinaseiiactivityinmousebrains

Ejemplares similares