Excision-reintegration at a pneumococcal phase-variable restriction-modification locus drives within- and between-strain epigenetic differentiation and inhibits gene acquisition

Phase-variation of Type I restriction-modification systems can rapidly alter the sequence motifs they target, diversifying both the epigenetic patterns and endonuclease activity within clonally descended populations. Here, we characterize the Streptococcus pneumoniae SpnIV phase-variable Type I RMS,...

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Detalles Bibliográficos
Autores principales: Kwun, Min Jung, Oggioni, Marco R, De Ste Croix, Megan, Bentley, Stephen D, Croucher, Nicholas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265443/
https://www.ncbi.nlm.nih.gov/pubmed/30321375
http://dx.doi.org/10.1093/nar/gky906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265443/
https://www.ncbi.nlm.nih.gov/pubmed/30321375
http://dx.doi.org/10.1093/nar/gky906

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