Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation

Runt-related transcription factor 1 (RUNX1) is a well-known master regulator of hematopoietic lineages but its mechanisms of action are still not fully understood. Here, we found that RUNX1 localizes on active chromatin together with Far Upstream Binding Protein 1 (FUBP1) in human B-cell precursor l...

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Detalles Bibliográficos
Autores principales: Debaize, Lydie, Jakobczyk, Hélène, Avner, Stéphane, Gaudichon, Jérémie, Rio, Anne-Gaëlle, Sérandour, Aurélien A, Dorsheimer, Lena, Chalmel, Frédéric, Carroll, Jason S, Zörnig, Martin, Rieger, Michael A, Delalande, Olivier, Salbert, Gilles, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265458/
https://www.ncbi.nlm.nih.gov/pubmed/30500954
http://dx.doi.org/10.1093/nar/gky756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265458/
https://www.ncbi.nlm.nih.gov/pubmed/30500954
http://dx.doi.org/10.1093/nar/gky756

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