Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1

Human flap endonuclease 1 (hFEN1) is a structure-specific nuclease essential for DNA replication and repair processes. hFEN1 has 5′ flap removal activity, as well as gap endonuclease activity that is critical for restarting stalled replication forks. Here, we report the crystal structures of wild-ty...

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Detalles Bibliográficos
Autores principales: Xu, Hong, Shi, Rongyi, Han, Wanchun, Cheng, Jiahui, Xu, Xiaoli, Cheng, Kaiying, Wang, Liangyan, Tian, Bing, Zheng, Li, Shen, Binghui, Hua, Yuejin, Zhao, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265464/
https://www.ncbi.nlm.nih.gov/pubmed/30295841
http://dx.doi.org/10.1093/nar/gky911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265464/
https://www.ncbi.nlm.nih.gov/pubmed/30295841
http://dx.doi.org/10.1093/nar/gky911

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