Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1

Post-transcriptional modification of snRNA is central to spliceosome function. Usb1 is an exoribonuclease that shortens the oligo-uridine tail of U6 snRNA, resulting in a terminal 2′,3′ cyclic phosphate group in most eukaryotes, including humans. Loss of function mutations in human Usb1 cause the ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Nomura, Yuichiro, Roston, Daniel, Montemayor, Eric J, Cui, Qiang, Butcher, Samuel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265477/
https://www.ncbi.nlm.nih.gov/pubmed/30215753
http://dx.doi.org/10.1093/nar/gky812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265477/
https://www.ncbi.nlm.nih.gov/pubmed/30215753
http://dx.doi.org/10.1093/nar/gky812

Ejemplares similares