Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks

Repair of DNA double-strand breaks (DSBs) requires eviction of the histones around DNA breaks to allow the loading of numerous repair and checkpoint proteins. However, the mechanism and regulation of this process remain poorly understood. Here, we show that histone H2B ubiquitination (uH2B) promotes...

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Detalles Bibliográficos
Autores principales: Zheng, Sihao, Li, Dan, Lu, Zhen, Liu, Guangxue, Wang, Meng, Xing, Poyuan, Wang, Min, Dong, Yang, Wang, Xuejie, Li, Jingyao, Zhang, Simin, Peng, Haoyang, Ira, Grzegorz, Li, Guohong, Chen, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265479/
https://www.ncbi.nlm.nih.gov/pubmed/30304473
http://dx.doi.org/10.1093/nar/gky918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265479/
https://www.ncbi.nlm.nih.gov/pubmed/30304473
http://dx.doi.org/10.1093/nar/gky918

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