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Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study

Background: Conflicting and population-dependent findings have been reported from epidemiological studies on the associations of dietary intake of anti-oxidant vitamins with cardiovascular events. We investigated the prospective relationship between dietary intake of anti-oxidant vitamins and incide...

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Autores principales: Lee, Chi-Ho, Chan, Ruth S. M., Wan, Helen Y. L., Woo, Yu-Cho, Cheung, Chloe Y. Y., Fong, Carol H. Y., Cheung, Bernard M. Y., Lam, Tai-Hing, Janus, Edward, Woo, Jean, Lam, Karen S. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265686/
https://www.ncbi.nlm.nih.gov/pubmed/30400367
http://dx.doi.org/10.3390/nu10111664
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author Lee, Chi-Ho
Chan, Ruth S. M.
Wan, Helen Y. L.
Woo, Yu-Cho
Cheung, Chloe Y. Y.
Fong, Carol H. Y.
Cheung, Bernard M. Y.
Lam, Tai-Hing
Janus, Edward
Woo, Jean
Lam, Karen S. L.
author_facet Lee, Chi-Ho
Chan, Ruth S. M.
Wan, Helen Y. L.
Woo, Yu-Cho
Cheung, Chloe Y. Y.
Fong, Carol H. Y.
Cheung, Bernard M. Y.
Lam, Tai-Hing
Janus, Edward
Woo, Jean
Lam, Karen S. L.
author_sort Lee, Chi-Ho
collection PubMed
description Background: Conflicting and population-dependent findings have been reported from epidemiological studies on the associations of dietary intake of anti-oxidant vitamins with cardiovascular events. We investigated the prospective relationship between dietary intake of anti-oxidant vitamins and incident adverse cardiovascular outcomes amongst Hong Kong Chinese. Methods: In this prospective population-based study, baseline dietary intake of anti-oxidant vitamins (A, C, and E) were assessed using a food frequency questionnaire in 875 Chinese participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) in 1995–1996. The adjusted hazard ratio (HR) of incident adverse cardiovascular outcomes, defined as the first recorded diagnosis of cardiovascular deaths, non-fatal myocardial infarction or non-fatal stroke, and coronary or other arterial revascularizations, was calculated per unit intake of each vitamin using multivariable Cox regression. Results: Over a median follow-up of 22 years, 85 participants (9.7%) developed adverse cardiovascular outcomes. Dietary intakes of vitamin A, C, and E were independently and inversely associated with incident adverse cardiovascular outcomes (HR 0.68, 95%CI 0.53–0.88, p = 0.003 for vitamin A; HR 0.66, 95%CI 0.52–0.85, p = 0.001 for vitamin C; and HR 0.57, 95%CI 0.38–0.86, p = 0.017 for vitamin E) after adjustments for conventional cardiovascular risk factors at baseline. Conclusions: Dietary intakes of anti-oxidant vitamins A, C, and E reduced the risk of adverse cardiovascular outcomes in Hong Kong Chinese.
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spelling pubmed-62656862018-12-06 Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study Lee, Chi-Ho Chan, Ruth S. M. Wan, Helen Y. L. Woo, Yu-Cho Cheung, Chloe Y. Y. Fong, Carol H. Y. Cheung, Bernard M. Y. Lam, Tai-Hing Janus, Edward Woo, Jean Lam, Karen S. L. Nutrients Article Background: Conflicting and population-dependent findings have been reported from epidemiological studies on the associations of dietary intake of anti-oxidant vitamins with cardiovascular events. We investigated the prospective relationship between dietary intake of anti-oxidant vitamins and incident adverse cardiovascular outcomes amongst Hong Kong Chinese. Methods: In this prospective population-based study, baseline dietary intake of anti-oxidant vitamins (A, C, and E) were assessed using a food frequency questionnaire in 875 Chinese participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) in 1995–1996. The adjusted hazard ratio (HR) of incident adverse cardiovascular outcomes, defined as the first recorded diagnosis of cardiovascular deaths, non-fatal myocardial infarction or non-fatal stroke, and coronary or other arterial revascularizations, was calculated per unit intake of each vitamin using multivariable Cox regression. Results: Over a median follow-up of 22 years, 85 participants (9.7%) developed adverse cardiovascular outcomes. Dietary intakes of vitamin A, C, and E were independently and inversely associated with incident adverse cardiovascular outcomes (HR 0.68, 95%CI 0.53–0.88, p = 0.003 for vitamin A; HR 0.66, 95%CI 0.52–0.85, p = 0.001 for vitamin C; and HR 0.57, 95%CI 0.38–0.86, p = 0.017 for vitamin E) after adjustments for conventional cardiovascular risk factors at baseline. Conclusions: Dietary intakes of anti-oxidant vitamins A, C, and E reduced the risk of adverse cardiovascular outcomes in Hong Kong Chinese. MDPI 2018-11-04 /pmc/articles/PMC6265686/ /pubmed/30400367 http://dx.doi.org/10.3390/nu10111664 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Chi-Ho
Chan, Ruth S. M.
Wan, Helen Y. L.
Woo, Yu-Cho
Cheung, Chloe Y. Y.
Fong, Carol H. Y.
Cheung, Bernard M. Y.
Lam, Tai-Hing
Janus, Edward
Woo, Jean
Lam, Karen S. L.
Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study
title Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study
title_full Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study
title_fullStr Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study
title_full_unstemmed Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study
title_short Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study
title_sort dietary intake of anti-oxidant vitamins a, c, and e is inversely associated with adverse cardiovascular outcomes in chinese—a 22-years population-based prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265686/
https://www.ncbi.nlm.nih.gov/pubmed/30400367
http://dx.doi.org/10.3390/nu10111664
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