Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells

The protein p53 protects the organism against carcinogenic events by the induction of cell cycle arrest and DNA repair program upon DNA damage. Virtually all cancers inactivate p53 either by mutations/deletions of the TP53 gene or by boosting negative regulation of p53 activity. The overexpression o...

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Detalles Bibliográficos
Autores principales: Skalniak, Lukasz, Kocik, Justyna, Polak, Justyna, Skalniak, Anna, Rak, Monika, Wolnicka-Glubisz, Agnieszka, Holak, Tad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266412/
https://www.ncbi.nlm.nih.gov/pubmed/30352966
http://dx.doi.org/10.3390/cancers10110396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266412/
https://www.ncbi.nlm.nih.gov/pubmed/30352966
http://dx.doi.org/10.3390/cancers10110396

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