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Tailoring the AAV2 capsid vector for bone-targeting

BACKGROUND: Targeting specific tissues remains a major challenge to the promise of gene therapy. For example, several strategies have failed to target adeno-associated virus 2 (AAV2) vectors, to bone. We have evaluated in vitro and in vivo the affinity of an AAV2 vector to bone matrix, hydroxyapatit...

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Detalles Bibliográficos
Autores principales: Alméciga-Díaz, Carlos J., Montaño, Adriana M., Barrera, Luis A., Tomatsu, Shunji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266866/
https://www.ncbi.nlm.nih.gov/pubmed/30323349
http://dx.doi.org/10.1038/s41390-018-0095-8