Non-Coding Variants in BRCA1 and BRCA2 Genes: Potential Impact on Breast and Ovarian Cancer Predisposition

BRCA1 and BRCA2 are major breast cancer susceptibility genes whose pathogenic variants are associated with a significant increase in the risk of breast and ovarian cancers. Current genetic screening is generally limited to BRCA1/2 exons and intron/exon boundaries. Most identified pathogenic variants...

Descripción completa

Detalles Bibliográficos
Autores principales: Santana dos Santos, Elizabeth, Lallemand, François, Burke, Leslie, Stoppa-Lyonnet, Dominique, Brown, Melissa, Caputo, Sandrine M., Rouleau, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266896/
https://www.ncbi.nlm.nih.gov/pubmed/30453575
http://dx.doi.org/10.3390/cancers10110453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266896/
https://www.ncbi.nlm.nih.gov/pubmed/30453575
http://dx.doi.org/10.3390/cancers10110453

Ejemplares similares