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Non-Coding Variants in BRCA1 and BRCA2 Genes: Potential Impact on Breast and Ovarian Cancer Predisposition

BRCA1 and BRCA2 are major breast cancer susceptibility genes whose pathogenic variants are associated with a significant increase in the risk of breast and ovarian cancers. Current genetic screening is generally limited to BRCA1/2 exons and intron/exon boundaries. Most identified pathogenic variants...

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Detalles Bibliográficos
Autores principales:	Santana dos Santos, Elizabeth, Lallemand, François, Burke, Leslie, Stoppa-Lyonnet, Dominique, Brown, Melissa, Caputo, Sandrine M., Rouleau, Etienne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266896/ https://www.ncbi.nlm.nih.gov/pubmed/30453575 http://dx.doi.org/10.3390/cancers10110453

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