Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition

In general, expression of transglutaminase 2 (TGase 2) is upregulated in renal cell carcinoma (RCC), resulting in p53 instability. Previous studies show that TGase 2 binds to p53 and transports it to the autophagosome. Knockdown or inhibition of TGase 2 in RCC induces p53-mediated apoptosis. Here, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Seon-Hyeong, Lee, Won-Kyu, Kim, Nayeon, Kang, Joon Hee, Kim, Kyung-Hee, Kim, Seul-Gi, Lee, Jae-Seon, Lee, Soohyun, Lee, Jongkook, Joo, Jungnam, Kwon, Woo Sun, Rha, Sun Young, Kim, Soo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267221/
https://www.ncbi.nlm.nih.gov/pubmed/30463244
http://dx.doi.org/10.3390/cancers10110455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267221/
https://www.ncbi.nlm.nih.gov/pubmed/30463244
http://dx.doi.org/10.3390/cancers10110455

Ejemplares similares