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Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition

In general, expression of transglutaminase 2 (TGase 2) is upregulated in renal cell carcinoma (RCC), resulting in p53 instability. Previous studies show that TGase 2 binds to p53 and transports it to the autophagosome. Knockdown or inhibition of TGase 2 in RCC induces p53-mediated apoptosis. Here, w...

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Detalles Bibliográficos
Autores principales:	Lee, Seon-Hyeong, Lee, Won-Kyu, Kim, Nayeon, Kang, Joon Hee, Kim, Kyung-Hee, Kim, Seul-Gi, Lee, Jae-Seon, Lee, Soohyun, Lee, Jongkook, Joo, Jungnam, Kwon, Woo Sun, Rha, Sun Young, Kim, Soo-Youl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267221/ https://www.ncbi.nlm.nih.gov/pubmed/30463244 http://dx.doi.org/10.3390/cancers10110455

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