Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release

Heterozygous mutations of the Forkhead-box protein 2 (FOXP2) gene in humans cause childhood apraxia of speech. Loss of Foxp2 in mice is known to affect striatal development and impair motor skills. However, it is unknown if striatal excitatory/inhibitory balance is affected during development and if...

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Detalles Bibliográficos
Autores principales: van Rhijn, Jon-Ruben, Fisher, Simon E., Vernes, Sonja C., Nadif Kasri, Nael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267273/
https://www.ncbi.nlm.nih.gov/pubmed/30187194
http://dx.doi.org/10.1007/s00429-018-1746-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267273/
https://www.ncbi.nlm.nih.gov/pubmed/30187194
http://dx.doi.org/10.1007/s00429-018-1746-6

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