Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings

BACKGROUND AND OBJECTIVE: Baloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. This first-in-human phase I study evaluated the safety, tolerability, and pharmacokinetics of baloxavir marboxil/baloxavir acid in hea...

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Detalles Bibliográficos
Autores principales: Koshimichi, Hiroki, Ishibashi, Toru, Kawaguchi, Nao, Sato, Chisako, Kawasaki, Akira, Wajima, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267547/
https://www.ncbi.nlm.nih.gov/pubmed/30288682
http://dx.doi.org/10.1007/s40261-018-0710-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267547/
https://www.ncbi.nlm.nih.gov/pubmed/30288682
http://dx.doi.org/10.1007/s40261-018-0710-9

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