Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma

Double-hit (DH) or double-expresser (DE) lymphomas are high-grade diffuse large B-cell lymphomas (DLBCL) that are mostly incurable with standard chemo-immunotherapy due to treatment resistance. The generation of drug-induced aneuploid/polyploid (DIAP) cells is a common effect of anti-DLBCL therapies...

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Detalles Bibliográficos
Autores principales: Islam, Shariful, Paek, Andrew L., Hammer, Michael, Rangarajan, Savithri, Ruijtenbeek, Robert, Cooke, Laurence, Weterings, Eric, Mahadevan, Daruka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267596/
https://www.ncbi.nlm.nih.gov/pubmed/30542505
http://dx.doi.org/10.18632/oncotarget.26251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267596/
https://www.ncbi.nlm.nih.gov/pubmed/30542505
http://dx.doi.org/10.18632/oncotarget.26251

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