Cargando…

Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma

Double-hit (DH) or double-expresser (DE) lymphomas are high-grade diffuse large B-cell lymphomas (DLBCL) that are mostly incurable with standard chemo-immunotherapy due to treatment resistance. The generation of drug-induced aneuploid/polyploid (DIAP) cells is a common effect of anti-DLBCL therapies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Islam, Shariful, Paek, Andrew L., Hammer, Michael, Rangarajan, Savithri, Ruijtenbeek, Robert, Cooke, Laurence, Weterings, Eric, Mahadevan, Daruka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267596/ https://www.ncbi.nlm.nih.gov/pubmed/30542505 http://dx.doi.org/10.18632/oncotarget.26251

Ejemplares similares

Co-targeting aurora kinase with PD-L1 and PI3K abrogates immune checkpoint mediated proliferation in peripheral T-cell lymphoma: a novel therapeutic strategy
por: Islam, Shariful, et al.
Publicado: (2017)

Alisertib Added to Rituximab and Vincristine Is Synthetic Lethal and Potentially Curative in Mice with Aggressive DLBCL Co-Overexpressing MYC and BCL2
por: Mahadevan, Daruka, et al.
Publicado: (2014)

Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target
por: Pandey, Ritu, et al.
Publicado: (2019)

Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy
por: Dörnen, Jessica, et al.
Publicado: (2020)

Different cell fates after mitotic slippage: From aneuploidy to polyploidy
por: Ohashi, Akihiro
Publicado: (2015)

The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress
por: Vande Zande, Pétra, et al.
Publicado: (2023)

L'aneuploïdie et la polyploïdie dans les cultures de cellules bovines
por: Cribiu, EP, et al.
Publicado: (1977)

Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy
por: Chen, X.-B., et al.
Publicado: (2005)

Myc promotes polyploidy in murine trophoblast cells and suppresses senescence
por: Singh, Vijay Pratap, et al.
Publicado: (2023)

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma
por: Portelinha, Ana, et al.
Publicado: (2023)

L'Aneuploïdie et la Polyploïdie chez les bovins dans les cultures de cellules bovines
por: Cribiu, EP, et al.
Publicado: (1977)

Oncogene-like addiction to aneuploidy in human cancers
por: Girish, Vishruth, et al.
Publicado: (2023)

Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature
por: Vazquez-Martin, Alejandro, et al.
Publicado: (2016)

Role of Bcl-2 on drug resistance in breast cancer polyploidy-induced spindle poisons
por: Yuan, Bibo, et al.
Publicado: (2020)

Expression Levels of RAD51 Inversely Correlate with Survival of Glioblastoma Patients
por: Morrison, Christopher, et al.
Publicado: (2021)

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer
por: Qi, Wenqing, et al.
Publicado: (2015)

Chromosome-level genome editing uncovers aneuploidy addiction in cancer
por: O’Brien, Siobhan, et al.
Publicado: (2023)

A bioclinical prognostic model using MYC and BCL2 predicts outcome in relapsed/refractory diffuse large B-cell lymphoma
por: Bosch, Mark, et al.
Publicado: (2018)

The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells
por: Welsh, James W, et al.
Publicado: (2009)

Razoxane-induced polyploidy.
por: Taylor, I. W., et al.
Publicado: (1978)

The expanding implications of polyploidy
por: Schoenfelder, Kevin P., et al.
Publicado: (2015)

Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring
por: Anatskaya, Olga V., et al.
Publicado: (2022)

Molecularly Stratified Treatment Options in Primary Refractory DLBCL/HGBL with MYC and BCL2 or BCL6 Rearrangements (HGBL, NOS with MYC/BCL6)
por: Witte, Hanno M., et al.
Publicado: (2023)

Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
por: Li, Weiping, et al.
Publicado: (2019)

Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells
por: Zamora, Ruben, et al.
Publicado: (2010)

Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells
por: Zhou, Weihua, et al.
Publicado: (2015)

Primary cutaneous diffuse large B‐cell lymphoma, leg type with MYC/BCL2/BCL6 overexpression
por: Okada, Yosuke, et al.
Publicado: (2021)

Regulated Polyploidy in Halophilic Archaea
por: Breuert, Sebastian, et al.
Publicado: (2006)

Polyploidy Induces Centromere Association
por: Martinez-Perez, Enrique, et al.
Publicado: (2000)

Polyploidy and the Evolution of Complex Traits
por: Huminiecki, Lukasz, et al.
Publicado: (2012)

Polyploidy and the petal transcriptome of Gossypium
por: Rambani, Aditi, et al.
Publicado: (2014)

Revisiting ancestral polyploidy in plants
por: Ruprecht, Colin, et al.
Publicado: (2017)

Polyploidy in the adult Drosophila brain
por: Nandakumar, Shyama, et al.
Publicado: (2020)

Synthetic Polyploidy in Grafted Crops
por: Ruiz, Marta, et al.
Publicado: (2020)

Editorial: Artificial Polyploidy in Plants
por: Chen, Jen-Tsung, et al.
Publicado: (2020)

TP53 Mutations as a Driver of Metastasis Signaling in Advanced Cancer Patients
por: Pandey, Ritu, et al.
Publicado: (2021)

Copy Number Alteration and Mutational Profile of High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements, Diffuse Large B-Cell Lymphoma with MYC-Rearrangement, and Diffuse Large B-Cell Lymphoma with MYC-Cluster Amplification
por: Miyaoka, Masashi, et al.
Publicado: (2022)

Diffuse Large B-Cell Lymphoma in Kenya: MYC, BCL2, and the Cell of Origin
por: Wawire, Jonathan, et al.
Publicado: (2019)

Oncogene addiction to c-MYC in myeloma cells
por: Holien, Toril, et al.
Publicado: (2012)

Inferior survival in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements is not associated with MYC/IG gene rearrangements
por: McPhail, Ellen D., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5brvauuhbh126qrf6j5g6f9h48