Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke

Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3...

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Autores principales: Choi, Ji Young, Na, MinKyun, Hyun Hwang, In, Ho Lee, Seung, Young Bae, Eun, Yeon Kim, Bo, Seog Ahn, Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267619/
https://www.ncbi.nlm.nih.gov/pubmed/19136914
http://dx.doi.org/10.3390/molecules14010266
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author Choi, Ji Young
Na, MinKyun
Hyun Hwang, In
Ho Lee, Seung
Young Bae, Eun
Yeon Kim, Bo
Seog Ahn, Jong
author_facet Choi, Ji Young
Na, MinKyun
Hyun Hwang, In
Ho Lee, Seung
Young Bae, Eun
Yeon Kim, Bo
Seog Ahn, Jong
author_sort Choi, Ji Young
collection PubMed
description Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors.
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spelling pubmed-62676192018-12-06 Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke Choi, Ji Young Na, MinKyun Hyun Hwang, In Ho Lee, Seung Young Bae, Eun Yeon Kim, Bo Seog Ahn, Jong Molecules Article Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors. Molecular Diversity Preservation International 2008-01-08 /pmc/articles/PMC6267619/ /pubmed/19136914 http://dx.doi.org/10.3390/molecules14010266 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Choi, Ji Young
Na, MinKyun
Hyun Hwang, In
Ho Lee, Seung
Young Bae, Eun
Yeon Kim, Bo
Seog Ahn, Jong
Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke
title Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke
title_full Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke
title_fullStr Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke
title_full_unstemmed Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke
title_short Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke
title_sort isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1b inhibitory activity from the roots of saussurea lappa c.b.clarke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267619/
https://www.ncbi.nlm.nih.gov/pubmed/19136914
http://dx.doi.org/10.3390/molecules14010266
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