Cargando…
Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver
BACKGROUND: Schisandrin B (Sch B) a main active component of Schisandra chinensis, has been shown to act as a liver protectant via activation of the Nrf2 pathway. Nevertheless, it remains unclear whether its reactive metabolite is responsible for Nrf2 activation; also, the effects of its reactive me...
Autores principales: | Feng, Shan, Qiu, Bingxun, Zou, Li, Liu, Ke, Xu, Xiaoyu, Zhu, Huifeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267698/ https://www.ncbi.nlm.nih.gov/pubmed/30568426 http://dx.doi.org/10.2147/DDDT.S176561 |
Ejemplares similares
-
Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
por: Han, Jibo, et al.
Publicado: (2018) -
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling
por: Ko, Yeonjin, et al.
Publicado: (2023) -
Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling
por: Ni, Shuo, et al.
Publicado: (2020) -
Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010) -
Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response
por: Leong, Pou Kuan, et al.
Publicado: (2016)