The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia

BACKGROUND: The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondrial DNA. Therefore MTH1 was proposed to protect cancer cells from oxidative DNA l...

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Detalles Bibliográficos
Autores principales: Pompsch, Mosche, Vogel, Julia, Classen, Fabian, Kranz, Philip, Iliakis, George, Riffkin, Helena, Brockmeier, Ulf, Metzen, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267833/
https://www.ncbi.nlm.nih.gov/pubmed/30497423
http://dx.doi.org/10.1186/s12885-018-5095-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267833/
https://www.ncbi.nlm.nih.gov/pubmed/30497423
http://dx.doi.org/10.1186/s12885-018-5095-x

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