Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model

BACKGROUND: Lipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative conditions. Interestingly, both neuroprotective and neurodegenerative effects have been described for Lcn2. Increased Lcn2 levels were found in human post-mortem Alzheimer (AD) brain tissue, and in vitr...

Descripción completa

Detalles Bibliográficos
Autores principales: Dekens, Doortje W., Naudé, Petrus J. W., Keijser, Jan N., Boerema, Ate S., De Deyn, Peter P., Eisel, Ulrich L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267886/
https://www.ncbi.nlm.nih.gov/pubmed/30501637
http://dx.doi.org/10.1186/s12974-018-1372-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267886/
https://www.ncbi.nlm.nih.gov/pubmed/30501637
http://dx.doi.org/10.1186/s12974-018-1372-5

Ejemplares similares