New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)(3), in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1–8 were obtained in moderate to good yields under mild conditions. This key st...

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Detalles Bibliográficos
Autores principales: Bouhlel, Ahlem, Curti, Christophe, Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268072/
https://www.ncbi.nlm.nih.gov/pubmed/22491680
http://dx.doi.org/10.3390/molecules17044313
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author Bouhlel, Ahlem
Curti, Christophe
Vanelle, Patrice
author_facet Bouhlel, Ahlem
Curti, Christophe
Vanelle, Patrice
author_sort Bouhlel, Ahlem
collection PubMed
description A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)(3), in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1–8 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.
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spelling pubmed-62680722018-12-11 New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate Bouhlel, Ahlem Curti, Christophe Vanelle, Patrice Molecules Communication A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)(3), in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1–8 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential. MDPI 2012-04-10 /pmc/articles/PMC6268072/ /pubmed/22491680 http://dx.doi.org/10.3390/molecules17044313 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Bouhlel, Ahlem
Curti, Christophe
Vanelle, Patrice
New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
title New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
title_full New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
title_fullStr New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
title_full_unstemmed New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
title_short New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
title_sort new methodology for the synthesis of thiobarbiturates mediated by manganese(iii) acetate
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268072/
https://www.ncbi.nlm.nih.gov/pubmed/22491680
http://dx.doi.org/10.3390/molecules17044313
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