Design and Synthesis of a Series of Pyrido[2,3-d]pyrimidine Derivatives as CCR4 Antagonists

A series of pyrido[2,3-d]pyrimidine derivatives were designed and synthesized based on known CC chemokine receptor 4 (CCR4) antagonists. The activities of all the newly synthesized compounds were evaluated using a chemotaxis inhibition assay. Compound 6b was proven to be a potent CCR4 antagonist tha...

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Detalles Bibliográficos
Autores principales: Gong, Hongwei, Qi, Hui, Sun, Wei, Zhang, Yang, Jiang, Dan, Xiao, Junhai, Yang, Xiaohong, Wang, Ying, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268086/
https://www.ncbi.nlm.nih.gov/pubmed/22907157
http://dx.doi.org/10.3390/molecules17089961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268086/
https://www.ncbi.nlm.nih.gov/pubmed/22907157
http://dx.doi.org/10.3390/molecules17089961

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