Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were id...

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Autores principales: Yao, Shuyi, Xie, Hui, Zhang, Li, Meng, Tao, Zhang, Yongliang, Wang, Xin, Chen, Lin, Pan, Shengli, Shen, Jingkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268093/
https://www.ncbi.nlm.nih.gov/pubmed/22306832
http://dx.doi.org/10.3390/molecules17021425
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author Yao, Shuyi
Xie, Hui
Zhang, Li
Meng, Tao
Zhang, Yongliang
Wang, Xin
Chen, Lin
Pan, Shengli
Shen, Jingkang
author_facet Yao, Shuyi
Xie, Hui
Zhang, Li
Meng, Tao
Zhang, Yongliang
Wang, Xin
Chen, Lin
Pan, Shengli
Shen, Jingkang
author_sort Yao, Shuyi
collection PubMed
description The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.
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spelling pubmed-62680932018-12-10 Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives Yao, Shuyi Xie, Hui Zhang, Li Meng, Tao Zhang, Yongliang Wang, Xin Chen, Lin Pan, Shengli Shen, Jingkang Molecules Article The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds. MDPI 2012-02-03 /pmc/articles/PMC6268093/ /pubmed/22306832 http://dx.doi.org/10.3390/molecules17021425 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yao, Shuyi
Xie, Hui
Zhang, Li
Meng, Tao
Zhang, Yongliang
Wang, Xin
Chen, Lin
Pan, Shengli
Shen, Jingkang
Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
title Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
title_full Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
title_fullStr Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
title_full_unstemmed Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
title_short Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
title_sort total synthesis and antidepressant activities of laetispicine and its derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268093/
https://www.ncbi.nlm.nih.gov/pubmed/22306832
http://dx.doi.org/10.3390/molecules17021425
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