Design, Practical Synthesis, and Biological Evaluation of Novel 6-(Pyrazolylmethyl)-4-quinoline-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors

A series of novel 6-(pyrazolylmethyl)-4-oxo-4H-quinoline-3-carboxylic acid derivatives bearing different substituents on the N-position of quinoline ring were designed and synthesized as potential HIV-1 integrase (IN) inhibitors, based on the structurally related GS-9137 scaffold. The structures of...

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Detalles Bibliográficos
Autores principales: Hu, Liming, Yan, Song, Luo, Zaigang, Han, Xiao, Wang, Yujie, Wang, Zhanyang, Zeng, Chengchu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268108/
https://www.ncbi.nlm.nih.gov/pubmed/22955454
http://dx.doi.org/10.3390/molecules170910652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268108/
https://www.ncbi.nlm.nih.gov/pubmed/22955454
http://dx.doi.org/10.3390/molecules170910652

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