Generation of the First Structure-Based Pharmacophore Model Containing a Selective “Zinc Binding Group” Feature to Identify Potential Glyoxalase-1 Inhibitors

Within this study, a unique 3D structure-based pharmacophore model of the enzyme glyoxalase-1 (Glo-1) has been revealed. Glo-1 is considered a zinc metalloenzyme in which the inhibitor binding with zinc atom at the active site is crucial. To our knowledge, this is the first pharmacophore model that...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Balas, Qosay, Hassan, Mohammad, Al-Oudat, Buthina, Alzoubi, Hassan, Mhaidat, Nizar, Almaaytah, Ammar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268171/
https://www.ncbi.nlm.nih.gov/pubmed/23174893
http://dx.doi.org/10.3390/molecules171213740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268171/
https://www.ncbi.nlm.nih.gov/pubmed/23174893
http://dx.doi.org/10.3390/molecules171213740

Ejemplares similares