Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

An efficient synthesis of a highly potent and selective IP (PGI(2) receptor) agonist that is not structurally analogous to PGI(2) is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl)-oxazolidin-2-one prepared by a one-pot proce...

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Detalles Bibliográficos
Autores principales: Morita, Yasuhiro, Ishigaki, Takeshi, Kawamura, Kuniaki, Hayashi, Ryoji, Isogaya, Masafumi, Kitsukawa, Mika, Miyamoto, Mitsuko, Uchida, Masashi, Iseki, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268181/
https://www.ncbi.nlm.nih.gov/pubmed/22293844
http://dx.doi.org/10.3390/molecules17021233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268181/
https://www.ncbi.nlm.nih.gov/pubmed/22293844
http://dx.doi.org/10.3390/molecules17021233

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