Strong Inhibition of Celastrol Towards UDP-Glucuronosyl Transferase (UGT) 1A6 and 2B7 Indicating Potential Risk of UGT-Based Herb-Drug Interaction

Celastrol, a quinone methide triterpene isolated from Tripterygium wilfordii Hook F., has various biochemical and pharmacological activities, and is now being developed as a promising anti-tumor agent. Inhibitory activity of compounds towards UDP-glucuronosyltransferase (UGT) is an important cause o...

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Detalles Bibliográficos
Autores principales: Zhang, Yong-Sheng, Tu, Yan-Yang, Gao, Xing-Chun, Yuan, Jun, Li, Gang, Wang, Liang, Deng, Jian-Ping, Wang, Qi, Ma, Ru-Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268241/
https://www.ncbi.nlm.nih.gov/pubmed/22669039
http://dx.doi.org/10.3390/molecules17066832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268241/
https://www.ncbi.nlm.nih.gov/pubmed/22669039
http://dx.doi.org/10.3390/molecules17066832

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