Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a (1)H-NMR Method to Assess Deacetylase Activity

The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases. Here we describe SAR studies starting from the unselective sirtuin inhibitor tenovin-6. These studies identify a sub...

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Detalles Bibliográficos
Autores principales: Pirrie, Lisa, McCarthy, Anna R., Major, Louise L., Morkūnaitė, Vaida, Zubrienė, Asta, Matulis, Daumantas, Lain, Sonia, Lebl, Tomas, Westwood, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268290/
https://www.ncbi.nlm.nih.gov/pubmed/23079492
http://dx.doi.org/10.3390/molecules171012206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268290/
https://www.ncbi.nlm.nih.gov/pubmed/23079492
http://dx.doi.org/10.3390/molecules171012206

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