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Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a (1)H-NMR Method to Assess Deacetylase Activity
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases. Here we describe SAR studies starting from the unselective sirtuin inhibitor tenovin-6. These studies identify a sub...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268290/ https://www.ncbi.nlm.nih.gov/pubmed/23079492 http://dx.doi.org/10.3390/molecules171012206 |