Design, Synthesis and Preliminary Pharmacological Evaluation of New Non-Steroidal Anti-Inflammatory Agents Having a 4-(Methylsulfonyl) Aniline Pharmacophore

A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme. In vivo acute anti-inflammatory activity of the final compounds 11–14 was evaluated in rat using an egg-white in...

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Detalles Bibliográficos
Autores principales: Mahdi, Monther Faisel, Mohammed, Mohamed Hassan, Jassim, Akeel Abdul Kadhum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268323/
https://www.ncbi.nlm.nih.gov/pubmed/22328075
http://dx.doi.org/10.3390/molecules17021751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268323/
https://www.ncbi.nlm.nih.gov/pubmed/22328075
http://dx.doi.org/10.3390/molecules17021751

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