Studies on 2-Arylhydrazononitriles: Synthesis of 3-Aryl-2-arylhydrazopropanenitriles and Their Utility as Precursors to 2-Substituted Indoles, 2-Substituted-1,2,3-Triazoles, and 1-Substituted Pyrazolo[4,3-d]pyrimidines

Coupling of 2-benzylmalononitrile with aromatic diazonium salts afforded 3-phenyl-2-arylhydrazonopropanenitriles 4a,b, which were rearranged into 2-cyanoindoles 5a,b upon heating with ZnCl(2) in the presence of glacial acetic acid. The produced indole derivatives 5a,b can be successfully used as val...

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Detalles Bibliográficos
Autores principales: Khalil, Khaled D., Al-Matar, Hamad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268339/
https://www.ncbi.nlm.nih.gov/pubmed/23079493
http://dx.doi.org/10.3390/molecules171012225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268339/
https://www.ncbi.nlm.nih.gov/pubmed/23079493
http://dx.doi.org/10.3390/molecules171012225

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