Enantioselective Synthesis of 2,2-Disubstituted Terminal Epoxides via Catalytic Asymmetric Corey-Chaykovsky Epoxidation of Ketones

Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li(3)-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted...

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Detalles Bibliográficos
Autores principales: Sone, Toshihiko, Yamaguchi, Akitake, Matsunaga, Shigeki, Shibasaki, Masakatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268480/
https://www.ncbi.nlm.nih.gov/pubmed/22314382
http://dx.doi.org/10.3390/molecules17021617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268480/
https://www.ncbi.nlm.nih.gov/pubmed/22314382
http://dx.doi.org/10.3390/molecules17021617

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