Synthesis and Antiangiogenic Activity of Novel Gambogic Acid Derivatives

Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity. Derivatives 4, 32, 35,36 effectively suppressed the formation of...

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Detalles Bibliográficos
Autores principales: Chen, Tao, Zhang, Rong-Hong, He, Shi-Chao, Xu, Qin-Yuan, Ma, Liang, Wang, Guang-Cheng, Qiu, Neng, Peng, Fei, Chen, Jin-Ying, Qiu, Jing-Xiang, Peng, Ai-Hua, Chen, Li-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268492/
https://www.ncbi.nlm.nih.gov/pubmed/22634837
http://dx.doi.org/10.3390/molecules17066249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268492/
https://www.ncbi.nlm.nih.gov/pubmed/22634837
http://dx.doi.org/10.3390/molecules17066249

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