Cargando…

Synthesis and Antiangiogenic Activity of Novel Gambogic Acid Derivatives

Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity. Derivatives 4, 32, 35,36 effectively suppressed the formation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Tao, Zhang, Rong-Hong, He, Shi-Chao, Xu, Qin-Yuan, Ma, Liang, Wang, Guang-Cheng, Qiu, Neng, Peng, Fei, Chen, Jin-Ying, Qiu, Jing-Xiang, Peng, Ai-Hua, Chen, Li-Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268492/ https://www.ncbi.nlm.nih.gov/pubmed/22634837 http://dx.doi.org/10.3390/molecules17066249

Ejemplares similares

Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG(2000) micelles
por: Cai, Lulu, et al.
Publicado: (2013)

Investigations into the antibacterial effects and potential mechanism of gambogic acid and neogambogic acid
por: Li, Mingzhu, et al.
Publicado: (2022)

Structural Optimization and Improving Antitumor Potential of Moreollic Acid from Gamboge
por: Cheng, Li-Zhi, et al.
Publicado: (2022)

Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs
por: Li, Meng, et al.
Publicado: (2022)

Gambogic Acid as a Candidate for Cancer Therapy: A Review
por: Liu, Yuling, et al.
Publicado: (2020)

Transcriptional Analysis of the Effects of Gambogic Acid and Neogambogic Acid on Methicillin-Resistant Staphylococcus aureus
por: Hua, Xin, et al.
Publicado: (2019)

A Gamboge Case
por: Biegler, J. A.
Publicado: (1887)

Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis
por: Wang, Shujun, et al.
Publicado: (2023)

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
por: Zhang, Zhen, et al.
Publicado: (2017)

Gambogic acid suppresses colon cancer cell activity in vitro
por: Zhou, Zailong, et al.
Publicado: (2019)

Synthesis and Antiangiogenic Activity of N-Alkylated Levamisole Derivatives
por: Hansen, Anders N., et al.
Publicado: (2012)

The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling
por: Qu, Jiaorong, et al.
Publicado: (2023)

Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines
por: Zou, Zhengyun, et al.
Publicado: (2012)

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
por: Yao, Jing, et al.
Publicado: (2014)

Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication
por: Choi, Eun J., et al.
Publicado: (2018)

Gambogic acid and juglone inhibit RNase P through distinct mechanisms
por: Wu Meyers, Nancy, et al.
Publicado: (2022)

Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner
por: Sui, Tongtong, et al.
Publicado: (2021)

Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway
por: Yu, Jiarui, et al.
Publicado: (2020)

Synergistic photothermal-photodynamic-chemotherapy toward breast cancer based on a liposome-coated core–shell AuNS@NMOFs nanocomposite encapsulated with gambogic acid
por: Li, Rong-Tian, et al.
Publicado: (2022)

Aminated β-cyclodextrin-grafted Fe(3)O(4)-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation
por: Fang, Wei, et al.
Publicado: (2019)

Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro
por: Chen, Jinhao, et al.
Publicado: (2015)

Nuclear Targeted Peptide Combined With Gambogic Acid for Synergistic Treatment of Breast Cancer
por: Dang, Wenli, et al.
Publicado: (2022)

Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
por: Lyu, Lei, et al.
Publicado: (2018)

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition
por: Shi, Xianping, et al.
Publicado: (2015)

Gambogic acid inhibits LPS-induced macrophage pro-inflammatory cytokine production mainly through suppression of the p38 pathway
por: Ma, Jianjun, et al.
Publicado: (2018)

Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer
por: Kebebe, Dereje, et al.
Publicado: (2019)

Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
por: Liu, Jianxin, et al.
Publicado: (2022)

Effects of magnetic nanoparticles of Fe(3)O(4) combinated with gambogic acid on apoptosis of SMMC-7721 cells
por: Tian, Liang, et al.
Publicado: (2015)

Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
por: WEN, CHUANGYU, et al.
Publicado: (2015)

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
por: He, Di, et al.
Publicado: (2009)

Gambogic acid reverses oxaliplatin resistance in colorectal cancer by increasing intracellular platinum levels
por: Wang, Qiang, et al.
Publicado: (2018)

Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment
por: Huang, Rui, et al.
Publicado: (2018)

Potential Application of Gambogic Acid for Retarding Renal Cyst Progression in Polycystic Kidney Disease
por: Khunpatee, Nutchanard, et al.
Publicado: (2022)

Carrier-Free Gambogic Acid Dimer Self-Assembly Nanomedicines for Rheumatoid Arthritis Treatment
por: Liu, Yuling, et al.
Publicado: (2023)

Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
por: Xu, Peipei, et al.
Publicado: (2013)

Cancer Cell Membrane-Coated Gambogic Acid Nanoparticles for Effective Anticancer Vaccination by Activating Dendritic Cells
por: Huang, Fengli, et al.
Publicado: (2023)

Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery of gambogic acid
por: Xu, Wei, et al.
Publicado: (2019)

Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo
por: Zhou, Yi, et al.
Publicado: (2016)

Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells
por: Chen, Baoan, et al.
Publicado: (2009)

Combined effects of low-dose gambogic acid and NaI(131) in drug-resistant non-small cell lung cancer cells
por: Huang, Jing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_188bek9cb75580lvj2mi2fvqp8