The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performan...

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Autores principales: Choe, Kang In, Kwon, Joo Hee, Park, Kwan Hee, Oh, Myeong Hwan, Kim, Manh Heun, Kim, Han Hyuk, Cho, Su Hyun, Chung, Eun Kyung, Ha, Sung Yi, Lee, Min Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268498/
https://www.ncbi.nlm.nih.gov/pubmed/23018923
http://dx.doi.org/10.3390/molecules171011484
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author Choe, Kang In
Kwon, Joo Hee
Park, Kwan Hee
Oh, Myeong Hwan
Kim, Manh Heun
Kim, Han Hyuk
Cho, Su Hyun
Chung, Eun Kyung
Ha, Sung Yi
Lee, Min Won
author_facet Choe, Kang In
Kwon, Joo Hee
Park, Kwan Hee
Oh, Myeong Hwan
Kim, Manh Heun
Kim, Han Hyuk
Cho, Su Hyun
Chung, Eun Kyung
Ha, Sung Yi
Lee, Min Won
author_sort Choe, Kang In
collection PubMed
description Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
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spelling pubmed-62684982018-12-12 The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR Choe, Kang In Kwon, Joo Hee Park, Kwan Hee Oh, Myeong Hwan Kim, Manh Heun Kim, Han Hyuk Cho, Su Hyun Chung, Eun Kyung Ha, Sung Yi Lee, Min Won Molecules Article Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity. MDPI 2012-09-27 /pmc/articles/PMC6268498/ /pubmed/23018923 http://dx.doi.org/10.3390/molecules171011484 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Choe, Kang In
Kwon, Joo Hee
Park, Kwan Hee
Oh, Myeong Hwan
Kim, Manh Heun
Kim, Han Hyuk
Cho, Su Hyun
Chung, Eun Kyung
Ha, Sung Yi
Lee, Min Won
The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
title The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
title_full The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
title_fullStr The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
title_full_unstemmed The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
title_short The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
title_sort antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of rhodiola sachalinensis a. bor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268498/
https://www.ncbi.nlm.nih.gov/pubmed/23018923
http://dx.doi.org/10.3390/molecules171011484
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