Weinreb Amidation as the Cornerstone of an Improved Synthetic Route to A-Ring-Modified Derivatives of Luotonin A

Weinreb amidation of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate with aromatic amines provides a significantly improved route to anilide-type key intermediates for the synthesis of the anticancer alkaloid, luotonin A, and new A-ring-modified derivatives thereof. This method has advantages conce...

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Detalles Bibliográficos
Autores principales: Haider, Norbert, Nuß, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268516/
https://www.ncbi.nlm.nih.gov/pubmed/23011278
http://dx.doi.org/10.3390/molecules171011363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268516/
https://www.ncbi.nlm.nih.gov/pubmed/23011278
http://dx.doi.org/10.3390/molecules171011363

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