Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications

A rapid LC-MS/MS method with good accuracy and sensitivity was developed and validated for the pharmacokinetics study of metoprolol (MP) in beagle dogs. The plasma samples were simply precipitated by methanol and then analyzed by LC-MS/MS. An Ultimate XB-C(18) column (150 × 2.1 mm ID, 5 μm) was used...

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Detalles Bibliográficos
Autores principales: Li, Sha, Wang, Xingli, Peng, Kelong, Ma, Zhiguo, Zhang, Xiaoqi, Fu, Shaolian, Li, Xiaofei, Li, Linlin, Hong, Aihua, Jiang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268535/
https://www.ncbi.nlm.nih.gov/pubmed/22391600
http://dx.doi.org/10.3390/molecules17032663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268535/
https://www.ncbi.nlm.nih.gov/pubmed/22391600
http://dx.doi.org/10.3390/molecules17032663

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