Synthesis of Potent Inhibitors of β-Ketoacyl-Acyl Carrier Protein Synthase III as Potential Antimicrobial Agents

Mycobacterium tuberculosis FabH, an essential enzyme in the mycolic acid biosynthetic pathway, is an attractive target for novel anti-tubercolosis agents. Structure-based design and synthesis of 1-(4-carboxybutyl)-4-(4-(substituted benzyloxy)phenyl)-1H-pyrrole-2-carboxylic acid derivatives 7a–h, a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yan, Zhong, Wu, Li, Rui-Juan, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268549/
https://www.ncbi.nlm.nih.gov/pubmed/22534662
http://dx.doi.org/10.3390/molecules17054770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268549/
https://www.ncbi.nlm.nih.gov/pubmed/22534662
http://dx.doi.org/10.3390/molecules17054770

Ejemplares similares