Syntheses and Cell-Based Phenotypic Screen of Novel 7-Amino pyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives as Potential Antiproliferative Agents

A series of N-3-substituted 7-aminopyrido[2,3-d]pyrimidin-6-carbonitrile derivatives was readily synthesized and their anti-proliferative activities on five types of tumor cells were evaluated through a cell-based phenotypic screening approach. Compound 3k was found to be potent on human colon cance...

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Detalles Bibliográficos
Autores principales: Yang, Tao, He, Hong, Ang, Wei, Yang, Ying-Hong, Yang, Jian-Zhong, Lin, Yan-Ni, Yang, Hua-Cheng, Pi, Wei-Yi, Li, Zi-Cheng, Zhao, Ying-Lan, Luo, You-Fu, Wei, Yuquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268601/
https://www.ncbi.nlm.nih.gov/pubmed/22367029
http://dx.doi.org/10.3390/molecules17032351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268601/
https://www.ncbi.nlm.nih.gov/pubmed/22367029
http://dx.doi.org/10.3390/molecules17032351

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