Enhancement of Gene Silencing Effect and Membrane Permeability by Peptide-Conjugated 27-Nucleotide Small Interfering RNA

Two different sizes of siRNAs, of which one type was 21-nucleotide (nt) siRNA containing 2-nt dangling ends and the other type was 27-nt siRNA with blunt ends, were conjugated with a nuclear export signal peptide of HIV-1 Rev at the 5′-sense end. Processing by Dicer enzyme, cell membrane permeabilit...

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Detalles Bibliográficos
Autores principales: Kubo, Takanori, Yanagihara, Kazuyoshi, Sato, Yuichiro, Morita, Yasuhiro, Seyama, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268710/
https://www.ncbi.nlm.nih.gov/pubmed/22983148
http://dx.doi.org/10.3390/molecules170911089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268710/
https://www.ncbi.nlm.nih.gov/pubmed/22983148
http://dx.doi.org/10.3390/molecules170911089

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