QSAR Modeling on Benzo[c]phenanthridine Analogues as Topoisomerase I Inhibitors and Anti-cancer Agents

Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, hologram-QSAR, 2D-QSAR and 3D-QSAR models were developed for BCPs on topoisomerase I inbibitory activity and cytotoxicity against seven tumor cell l...

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Detalles Bibliográficos
Autores principales: Thai, Khac-Minh, Bui, Quang-Huynh, Tran, Thanh-Dao, Huynh, Thi-Ngoc-Phuong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268722/
https://www.ncbi.nlm.nih.gov/pubmed/22580401
http://dx.doi.org/10.3390/molecules17055690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268722/
https://www.ncbi.nlm.nih.gov/pubmed/22580401
http://dx.doi.org/10.3390/molecules17055690

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