Application of 4D-QSAR Studies to a Series of Raloxifene Analogs and Design of Potential Selective Estrogen Receptor Modulators

Four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis was applied on a series of 54 2-arylbenzothiophene derivatives, synthesized by Grese and coworkers, based on raloxifene (an estrogen receptor-alpha antagonist), and evaluated as ERα ligands and as inhibitors of estrogen...

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Detalles Bibliográficos
Autores principales: Sodero, Ana Carolina Rennó, Romeiro, Nelilma Correia, da Cunha, Elaine Fontes Ferreira, de Oliveira Magalhães, Uiaran, de Alencastro, Ricardo Bicca, Rodrigues, Carlos Rangel, Cabral, Lúcio Mendes, Castro, Helena Carla, Albuquerque, Magaly Girão
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268799/
https://www.ncbi.nlm.nih.gov/pubmed/22706372
http://dx.doi.org/10.3390/molecules17067415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268799/
https://www.ncbi.nlm.nih.gov/pubmed/22706372
http://dx.doi.org/10.3390/molecules17067415

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