Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

Nevirapine (NVP) is an anti-HIV drug associated with severe hepatotoxicity and skin rashes, which raises concerns about its chronic administration. There is increasing evidence that metabolic activation to reactive electrophiles capable of reacting with bionucleophiles is likely to be involved in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Antunes, Alexandra M. M., Sidarus, Muna, Novais, David A., Harjivan, Shrika G., Santos, Pedro P., da Silva, João L. Ferreira, Beland, Frederick A., Marques, M. Matilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268841/
https://www.ncbi.nlm.nih.gov/pubmed/22391597
http://dx.doi.org/10.3390/molecules17032616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268841/
https://www.ncbi.nlm.nih.gov/pubmed/22391597
http://dx.doi.org/10.3390/molecules17032616

Ejemplares similares