Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, an Impurity of Acyclovir

The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce th...

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Detalles Bibliográficos
Autores principales: Suárez, Rosa M., Matía, Maria Paz, Novella, José Luis, Molina, Andres, Cosme, Antonio, Vaquero, Juan José, Alvarez-Builla, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268874/
https://www.ncbi.nlm.nih.gov/pubmed/22832875
http://dx.doi.org/10.3390/molecules17088735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268874/
https://www.ncbi.nlm.nih.gov/pubmed/22832875
http://dx.doi.org/10.3390/molecules17088735

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