Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles

In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf(2)NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a s...

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Detalles Bibliográficos
Autores principales: Saito, Akio, Hyodo, Nao, Hanzawa, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268898/
https://www.ncbi.nlm.nih.gov/pubmed/22976468
http://dx.doi.org/10.3390/molecules170911046
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author Saito, Akio
Hyodo, Nao
Hanzawa, Yuji
author_facet Saito, Akio
Hyodo, Nao
Hanzawa, Yuji
author_sort Saito, Akio
collection PubMed
description In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf(2)NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.
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spelling pubmed-62688982018-12-12 Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles Saito, Akio Hyodo, Nao Hanzawa, Yuji Molecules Article In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf(2)NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions. MDPI 2012-09-13 /pmc/articles/PMC6268898/ /pubmed/22976468 http://dx.doi.org/10.3390/molecules170911046 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Saito, Akio
Hyodo, Nao
Hanzawa, Yuji
Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
title Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
title_full Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
title_fullStr Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
title_full_unstemmed Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
title_short Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
title_sort synthesis of highly substituted oxazoles through iodine(iii)-mediated reactions of ketones with nitriles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268898/
https://www.ncbi.nlm.nih.gov/pubmed/22976468
http://dx.doi.org/10.3390/molecules170911046
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AT hyodonao synthesisofhighlysubstitutedoxazolesthroughiodineiiimediatedreactionsofketoneswithnitriles
AT hanzawayuji synthesisofhighlysubstitutedoxazolesthroughiodineiiimediatedreactionsofketoneswithnitriles

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