A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue

The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro-5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phos...

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Detalles Bibliográficos
Autores principales: D’Errico, Stefano, Oliviero, Giorgia, Borbone, Nicola, Amato, Jussara, D’Alonzo, Daniele, Piccialli, Vincenzo, Mayol, Luciano, Piccialli, Gennaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268913/
https://www.ncbi.nlm.nih.gov/pubmed/23124472
http://dx.doi.org/10.3390/molecules171113036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268913/
https://www.ncbi.nlm.nih.gov/pubmed/23124472
http://dx.doi.org/10.3390/molecules171113036

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