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A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue
The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro-5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phos...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268913/ https://www.ncbi.nlm.nih.gov/pubmed/23124472 http://dx.doi.org/10.3390/molecules171113036 |
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| author | D’Errico, Stefano Oliviero, Giorgia Borbone, Nicola Amato, Jussara D’Alonzo, Daniele Piccialli, Vincenzo Mayol, Luciano Piccialli, Gennaro |
| author_facet | D’Errico, Stefano Oliviero, Giorgia Borbone, Nicola Amato, Jussara D’Alonzo, Daniele Piccialli, Vincenzo Mayol, Luciano Piccialli, Gennaro |
| author_sort | D’Errico, Stefano |
| collection | PubMed |
| description | The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro-5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phosphorylated to ZMP by cellular kinases, is reported. |
| format | Online Article Text |
| id | pubmed-6268913 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62689132018-12-13 A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue D’Errico, Stefano Oliviero, Giorgia Borbone, Nicola Amato, Jussara D’Alonzo, Daniele Piccialli, Vincenzo Mayol, Luciano Piccialli, Gennaro Molecules Communication The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro-5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phosphorylated to ZMP by cellular kinases, is reported. MDPI 2012-11-02 /pmc/articles/PMC6268913/ /pubmed/23124472 http://dx.doi.org/10.3390/molecules171113036 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Communication D’Errico, Stefano Oliviero, Giorgia Borbone, Nicola Amato, Jussara D’Alonzo, Daniele Piccialli, Vincenzo Mayol, Luciano Piccialli, Gennaro A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue |
| title | A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue |
| title_full | A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue |
| title_fullStr | A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue |
| title_full_unstemmed | A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue |
| title_short | A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue |
| title_sort | facile synthesis of 5′-fluoro-5′-deoxyacadesine (5′-f-aicar): a novel non-phosphorylable aicar analogue |
| topic | Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268913/ https://www.ncbi.nlm.nih.gov/pubmed/23124472 http://dx.doi.org/10.3390/molecules171113036 |
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